Curcumin alleviates fatigue symptomsCurcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.
Validates curcumin's effectiveness
We examined the connection between curcumin, a natural compound found in turmeric, and chronic fatigue syndrome in a mouse model. This model used purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigens to induce symptoms of fatigue.
The study involved a water-immersion stress test conducted for 10 minutes each day over 19 days. Notably, the mice treated with LPS or BA showed increased immobility time and heightened sensitivity to pain, which are markers for fatigue. As expected, these mice also exhibited elevated levels of tumor necrosis factor-alpha (TNF-alpha), a sign of inflammation.
Upon administering curcumin during this period, we observed significant improvements. The treatment reduced both the immobility time and pain sensitivity in the mice. Additionally, curcumin helped to lower oxidative stress and the levels of TNF-alpha.
These findings suggest that curcumin could be a promising option for addressing chronic fatigue syndrome, especially related to inflammation and oxidative stress. As we continue to explore this natural remedy, we may uncover more about its potential role in managing this challenging condition.
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